take care和take care of的区别有：1、意思不同：take care意思是：保重，注意(一般是跟别人道别的时候用)。take care of意思是：照顾，护理。2、用法不同：take care of后面要接名词，不可单独使用。take care可单独使用，后面不需要接成分。
take care造句示例：1、Take care! There’s a car coming towards you.当心，有辆车朝你开来了!2、Take care not to let these goods be rained on!当心别让这些货物被雨水淋湿了!3、Take care (that) you don’t drink too much/not to drink too much.当心别喝多了。4、He is in a bad temper this morning; take care not to step on his toes.他今天上午心情不好，当心一点，不要触犯他。
take care of造句示例：1、Take care of yourselves.你们自己照顾自己吧.2、Please take care of everything.以后请多关照.3、Take care of your health.关注你自己的健康.4、Have you is take care of?有人招呼您了吗?
“张承辉博客” take care和take care of的区别 https://www.zhangchenghui.com/245820